CROSS-CULTURAL PERSPECTIVES ON MENTAL HEALTH SHAME AMONG MALE WORKERS



Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target with inhibitors being tested in clinical colts dog collar trials.However, it remains unknown how the efficacy of PRMT5 inhibitors is regulated.Here we report that autophag

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Reversal of the Halo Effect: Prolonged Participation in Comprehensive Care for Joint Replacement Negatively Impacts Revision Metrics

Background: The downstream regional effect of the Comprehensive Care for Joint Replacement (CJR) program on care pathway-adjacent patients, including revision arthroplasty patients, is poorly understood.Prior studies have demonstrated that care pathways targeting primary total joint arthroplasty may produce a halo effect, impacting more complex pat

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